Although the bite of brown recluse spiders are rarely

Although the bite of brown recluse spiders are rarely fatal, they cause chronic flesh wounds, posing the greatest danger to the infant and elderly, who are particularly vulnerable to its poison.
(A) brown recluse spiders are rarely fatal, they cause chronic flesh wounds, posing the greatest danger to the infant and elderly, who are particularly vulnerable to its
(B) brown recluse spiders are rarely fatal, they cause chronic flesh wounds and pose the greatest danger to the infant and elderly, who are particularly vulnerable to their
(C) the brown recluse spider is rarely fatal, it causes chronic flesh wounds, posing the greatest danger to the infant and elderly, who are particularly vulnerable to their
(D) the brown recluse spider is rarely fatal, it causes chronic flesh wounds and poses the greatest danger to infants and the elderly, who are particularly vulnerable to its
(E) the brown recluse spider is rarely fatal, they cause chronic flesh wounds, posing the greatest danger to the infant and elderly, who are particularly vulnerable to its

Can some one help me to clraify my doubt
Can the pronoun's refer to the nouns which are in prepositional phrases
for eg:
bite of brown recluse spiders .In this if i want to refer to spiders can i use they eventhough they reside in prepositional phrase(bite of brown recluse spiders).
Please help me!!!